1-(4-Methoxyphenyl)-4-phenethylpiperazine → HCID 23111456, compound

HRID 269949Notes

Reaction equation

HRID 269949 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[Cl:23][C:24]1[CH:49]=[CH:48][C:27]([CH2:28][S:29]([N:32]2[CH2:37][CH2:36][N:35]([C:38]3[CH:43]=[C:42]([F:44])[C:41]([O:45]C)=[CH:40][C:39]=3[F:47])[CH2:34][CH2:33]2)(=[O:31])=[O:30])=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:49]=[CH:48][C:27]([CH2:28][S:29]([N:32]2[CH2:33][CH2:34][N:35]([C:38]3[CH:43]=[C:42]([F:44])[C:41]([OH:45])=[CH:40][C:39]=3[F:47])[CH2:36][CH2:37]2)(=[O:30])=[O:31])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 23111489HCID 23111489, compound

Product 1

HCID 23111456HCID 23111456, compoundYield 98.3%

Procedure

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-(4-chlorobenzylsulfonyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (400 mg), to provide crude 1-(4-chlorobenzylsulfonyl)-4-(2,5-difluoro-4-hydroxyphenyl)piperazine (380 mg).

Sources & evidence

ORD record
ord-890e2debd43041cd92597d67fdbfef22
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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