HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isovaleryl chloride → 4-(2,5-Difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isovaleryl chloride | HCID 66054 | — |
| Reactant | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| Reactant | 2-Phenylethane-1-sulfonyl chloride | HCID 2760374 | — |
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| Product | 4-(2,5-Difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine | HCID 23111470 | 101.3% |
Reaction Steps
Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (228 mg) and phenethylsulfonyl chloride (409 mg), respectively, to provide crude 4-(2,5-difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine (401 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-32b52a5ec05e46bea8ee38a9779b3e1a |
| Source note | uspto-grants-2008_11 |