Methanol → HCID 69309788, compound

Participants

Reaction Conditions

Reaction Steps

Add [3-(4-Nitro-phenyl)-propyl]-[2-(2,2,2-trifluoro-acetylamino)-ethyl]carbamic acid tert-butyl ester (16 g, 33 mmol), potassium carbonate (23 g, 170 mmol), methanol (100 mL) and water (45 mL) to a 500 mL flask. Heat to 50° C. for 1 hr. Cool the reaction and filter off any solids. Add dichloromethane and water, stir and separated the layers. Extract the aqueous layer with dichloromethane. Combine the organic layers, wash with brine, dry over MgSO4 and concentrate under reduced pressure to obtain the title compound as an oily residue. The title compound was used without purification. 1H NMR (CDCl3, 500.0 MHz): δ 8.13 (d, 2H, J=9 Hz), 7.32 (d, 2H, J=8.5 Hz), 3.24 (br m, 4H), 2.82 (br m, 2H), 2.69 (t, 2H, J=7.5 Hz), 1.87 (p, J=7.5 Hz), 1.48 (br s, 2H), 1.43 (s, 9H).

Provenance & Evidence