Methanol → HCID 11238729, compound

Participants

Reaction Steps

Add 4M HCl/dioxane solution (400 μL, 1.60 mmol) to a solution of [2,3-dihydroxy-3-(4-nitro-phenyl)-propyl]-[2-(7-phenyl-isoquinoline-5-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester (100 mg, 0.16 mmol in CH2Cl2 (3 mL) and CH3OH (2 mL) at room temperature under argon, and stir the mixture for 2 hours. Evaporate the solvent and wash the salt several times with Et2O and dry, to obtain the title compound. 1H NMR (CD3OD): δ9.95 (bs, 1H), 8.94-9.12 (m, 3H), 8.78 (m, 1H), 8.24 (m, 2H), 7.94 (m, 2H), 7.52-7.72 (m, 5H); 4.82-4.97 (m, 1H, under H2O signal), 4.07-4.15 (m, 1H), 3.05-3.31 (m, 6H).

Provenance & Evidence