Hydrochloric Acid → HCID 86610758, compound

Participants

Reaction Steps

To {2-[7-(4-hydroxy-phenyl)-isoquinoline-5-sulfonylamino]-ethyl}-[3-(4-nitro-phenyl)-propyl]-carbamic acid tert-butyl ester, (0.090 g, 0.148 mmol) in 6 ml (1:1) CH2Cl2/MeOH bubble HCl (g) for several minutes, then stir for 1 h and filter to give 0.0859 g of 7-(4-hydroxy-phenyl)-isoquinoline-5-sulfonic acid {2-[3-(4-nitro-phenyl)-propylamino]-ethyl}-amide dihydrochloric acid in 100% yield. ES Positive Ion MS [M+H]+ ion observed: m/z 507. 1H-NMR (DMSO-d6) δ9.62 (s, 1H), 8.93 (br s, 2H), 8.75 (s, 1H), 8.69-8.71 (m, 2H), 8.61 (s, 1H), 8.52 (d, J=6.2 Hz, 1H), 8.15 (d, J=8.8 Hz, 2H), 7.75 (d, J=8.8 Hz, 2H), 7.48 (d, J=8.8 Hz, 2H), 6.96 (d, J=8.4 Hz, 2H), 3.10-3.15 (br m, 2H), 2.90-3.00 (br s, 2H), 2.87 (br s, 2H), 2.75 (t, J=7.5 Hz; 2H), 1.87-1.90 (m, 2H).

Provenance & Evidence