Sodium borohydride → Benzenemethanol,2-benzo[b]thien-5-yl-

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 2-Benzo[b]thiophene-5-yl-benzaldehyde (compound PRE14) (3.31 g, 13.9 mmole) in methanol (30 mL) was added at 0-5° C. portionwise NaBH4 (0.528 g, 13.9 mmole). At the end of the addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 2 h. After concentration, the residue was diluted with water and diethyl ether, the organic layer dried over Na2SO4 and concentrated to give 3.13 g of compound O7 as an orange brown oil (Yield=94%).

Herkunft & Nachweise