1,4-Dioxane hydrochloride → HCID 22179861, compound

HRID 270018Notes

Reaction equation

HRID 270018 reaction equation
[N:1]1([C:7](=[O:29])[CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:30].O1CCOCC1>>[ClH:30].[ClH:30].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)=[O:29])=[CH:11][CH:12]=2)[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22179854Tert-butyl 4-[4-(3-morpholin-4-yl-3-oxopropyl)phenyl]piperazine-1-carboxylate

Product 1

HCID 22179861HCID 22179861, compound

Procedure

A mixture of Example 4C (317 mg, 0.787 mmol) in 4N HCl/dioxane was allowed to stand for 1 hour and concentrated to provide the desired product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-888d2b56462c4448abef6e01b3aefd9b
Source dataset
uspto-grants-2008_11
Patent number
US07449485B2

Reaction notes

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