反应详情

1′-benzyl-4H-spiro[chromene-3,4′-piperidine] (800 mg, 2.7 mmol) was dissolved in methanol (100 mL). Acetic acid (5 mL) and palladium on activated charcoal (cat amount, 10%) was added. Reaction in a Parr apparatus at 35 psi for 18 hrs, followed by filtration, evaporation and HPLC purification on C18 (acetonitrile/water) yielded 500 mg (92%) of the title compound.

1. customReaction in a Parr apparatus at 35 psi for 18 hrs
2. filtrationfollowed by filtration, evaporation and HPLC purification on C18 (acetonitrile/water)