反应详情

A solution of 1′-benzyl-6-chloro-3,4-dihydrospiro[chromene-2,4′-piperidine] (1.63 g, 5.0 mmol) and 1-chloroethyl chloroformate (1.07 g, 7.5 mmol) in toluene (5 ml) was heated with reflux overnight. The solvent was removed i. vacuo, the oily residue dissolved in methanol (10 ml) and heated with reflux overnight. The solvent was removed in vacuo, and the residue treated with diethyl ether (50 ml). The white precipitate was collected by filtration, washed with diethyl ether and dried to afford the subtitle compound as white powder (0.58 g, 49%).

1. temperaturewith reflux overnight
2. customThe solvent was removed i
3. dissolutionvacuo, the oily residue dissolved in methanol (10 ml)
4. temperatureheated
5. temperaturewith reflux overnight
6. customThe solvent was removed in vacuo
7. additionthe residue treated with diethyl ether (50 ml)
8. filtrationThe white precipitate was collected by filtration
9. washwashed with diethyl ether
10. customdried