HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-piperidone → HCID 67377897, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | 2-Bromo-5-fluorobenzoic acid | HCID 2778181 | — |
| Reactant | 1'-Benzyl-6-chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 12213047 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67377897 | HCID 67377897 | — |
Reaction Steps
This reaction was performed as described for (i) above using 2-bromo-5-fluorobenzoic acid (2.19 g, 10.0 mmol), 1-benzylpiperidin-4-one (3.78 g, 20.0 mmol), n-butyl lithium (n-BuLi) (20 mL) and THF (20 mL) to give the sub-titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449475B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-6270015648f2484cb820595c68701494 |
| Source note | uspto-grants-2008_11 |