反应详情

A suspension of methyl 4-fluoro-2-hydroxybenzoate (510 mg, 3.0 mmol) in cyclopropylamine (5 mL) was stirred at room temperature overnight when it became a clear solution. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether) to give the subtitled compound (493 mg).

1. customThe volatiles were removed in vacuo
2. customthe residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether)