HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylamino-5-benzoyloxyphenol → 4-(Acetylamino)-3-{[(2S)-2-methyloxiran-2-yl]methoxy}phenyl benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylamino-5-benzoyloxyphenol | HCID 68957620 | — |
| Reactant | HCID 86597620 | HCID 86597620 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(Acetylamino)-3-{[(2S)-2-methyloxiran-2-yl]methoxy}phenyl benzoate | HCID 86601479 | 39% |
Reaction Steps
This compound was prepared from 4-(acetylamino)-3-hydroxyphenyl benzoate (2.71 g, 10 mmol) and [(2S)-2-methyloxiran-2-yl]methyl 3-nitrobenzenesulfonate using the standard procedure and 1-methylpyrrolidin-2-one as a solvent. Flash chromatography on silica gel (ethyl acetate/n-heptane) afforded the subtitled compound as a colourless solid (1.31 g, 3.9 mmol, 39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449475B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5c40fa6ce3cf4fc0ba9c3efa236767a1 |
| Source note | uspto-grants-2008_11 |