Cyclopropylamine → HCID 68958982, compound

HRID 270081Notes

Reaction equation

HRID 270081 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH:22]1([NH2:25])[CH2:24][CH2:23]1>>[CH:22]1([NH:25][C:4](=[O:6])[C:3]2[CH:8]=[CH:9][C:10]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[CH:11][C:2]=2[OH:1])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 10541338Benzoic acid, 2-hydroxy-4-[(4-methoxyphenyl)methoxy]-, methyl ester

Product 1

HCID 68958982HCID 68958982, compound

Procedure

Methyl 2-hydroxy-4-[(4-methoxybenzyl)oxy]benzoate (Percec, V; Tomazos, D. J. Mater. Chem. 1993, 3, 643-650) (530 mg, 1.83 mmol) was dissolved in cyclopropyl amine (3 mL) and left at room temperature for a week. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (040% ethyl acetate in petroleum ether) to give the subtitled compound (407 mg).

Workup

  1. waitleft at room temperature for a week
  2. customThe volatiles were removed in vacuo
  3. customthe residue was purified by silica gel flash chromatography (040% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-534099d5f99f41a5817ae18e838d5ee1
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

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