HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorzoxazone → (3S)-N-(5-chloro-2-hydroxyphenyl)-3-hydroxypyrrolidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorzoxazone | HCID 2733 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Product | (3S)-N-(5-chloro-2-hydroxyphenyl)-3-hydroxypyrrolidine-1-carboxamide | HCID 68963403 | 880% |
Reaction Steps
5-chloro-1,3-benzoxazole-2(3H)-one (577 mg, 0.34 mmol) and (3S)-pyrrolidin-3-ol (0.6 mL, 0.74 mmol) was heated to 90° C. for 2 hrs. The resulting red solidified oil was purified on silica (dichloromethane/methanol) to give the titled compound (768 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449475B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-3c3f915fa0da416aa7c54c03394e10c0 |
| Source note | uspto-grants-2008_11 |