Hydrochloric Acid → 2-[[(2R)-3-Chloro-2-hydroxy-2-methylpropyl]oxy]-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

2-[[(2S)-2-Methyloxiranyl]methoxy]-1H-isoindole-1,3(2H)-dione (3.0 g, 12.9 mmol) was treated with concentrated hydrochloric acid (12 ml) and stirred at ambient temperature for 2 h. The mixture was partitioned between water and dichloromethane, the organics were dried and purified by chromatography (EtOAc) to give the sub-title compound as a colourless solid (3.3 g).

Provenance & Evidence