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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 270119Generated: October 30, 2026

N-Hydroxyphthalimide → 2-[[(2R)-2-Methyloxiranyl]methoxy]-1H-isoindole-1,3(2H)-dione

https://huagongshe.com/reaction/270119

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-HydroxyphthalimideHCID 10665—
ReactantHCID 57463982HCID 57463982—
Product2-[[(2R)-2-Methyloxiranyl]methoxy]-1H-isoindole-1,3(2H)-dioneHCID 86601488—

Reaction Steps

Prepared from N-hydroxyphthalimide and [(2R)-2-methyloxiran-2-yl]methyl 3-nitrobenzenesulfonate (Chen, J.; Shum, W., Tetrahedron Letters, 1993, 34(48), 7663-6) by the method of Example 93 Step I.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449475B2
Source datasetuspto-grants-2008_11
ORD IDord-72103af169b9403cb37864130d9940fb
Source noteuspto-grants-2008_11