HCID 835257, compound → HCID 68958602, compound

HRID 270133Notes

Reaction equation

HRID 270133 reaction equation
[Cl:1][C:2]1[C:3]([O:19]C)=[CH:4][C:5]([O:17]C)=[C:6]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1>C(Cl)Cl>[Cl:1][C:2]1[C:3]([OH:19])=[CH:4][C:5]([OH:17])=[C:6]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1

Participants

3

Reactant 1

HCID 835257HCID 835257, compound

Product 1

HCID 68958602HCID 68958602, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of N-(5-chloro-2,4-dimethoxyphenyl)benzamide (292 mg, 1 mmol) in DCM (10 mL) 1M boron tribromide in DCM (3 mL, 3 mmol) was added dropwise at ambient temperature. A precipitate was formed after 30 min. The stirring was continued over night. The mixture was quenched with methanol (5 mL) and concentrated in vacuo leaving an oil which was used without further purification.

Workup

  1. customA precipitate was formed after 30 min
  2. waitThe stirring was continued over night
  3. customThe mixture was quenched with methanol (5 mL)
  4. concentrationconcentrated in vacuo
  5. customleaving an oil which
  6. customwas used without further purification

Sources & evidence

ORD record
ord-bf8ac3a147684064b98c4e988e0b2746
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

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