HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 27022Generated: October 26, 2026
Benzoic Acid → 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide
https://huagongshe.com/reaction/27022
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N~1~,N~1~,N~3~,N~3~-Tetraethylbenzene-1,3-diamine | HCID 19382815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide | HCID 53894173 | — |
Reaction Steps
A mixture of 2-(4-dimethylamino)benzoyl)benzoic acid (8.07 g.), N,N,N',N'-tetraethyl-m-phenylenediamine (7.26 g.) and acetic anhydride (5 ml.) was heated (at 52° C.) during one and one-half hours. Addition of methanol (10 ml., then 15 ml.) afforded 3-(2,4-bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide (I: X=(CH3CH2)2N, Y2 =Z4 =Z5 =Z6 =Z7 =H, Y4 =(CH3)2N) (10.92 g., m.p. 117°-119° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04220357 |
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| Source dataset | uspto-grants-1980_09 |
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| ORD ID | ord-f30f47db2f8442358566541d361949ef |
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| Source note | uspto-grants-1980_09 |
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