2-(Methylamino)ethanol → 2-[[2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-ethyl]-methyl-amino]-ethanol

HRID 270276Notes

Reaction equation

HRID 270276 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:20]=[CH:19][C:8]2[C:9]([C:12]3[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=3)=[N:10][S:11][C:7]=2[CH:6]=1.[CH3:21][NH:22][CH2:23][CH2:24][OH:25]>>[Br:18][C:15]1[CH:16]=[CH:17][C:12]([C:9]2[C:8]3[CH:19]=[CH:20][C:5]([O:4][CH2:3][CH2:2][N:22]([CH3:21])[CH2:23][CH2:24][OH:25])=[CH:6][C:7]=3[S:11][N:10]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 22314138HCID 22314138, compound

Product 1

HCID 223138982-[[2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-ethyl]-methyl-amino]-ethanol

Procedure

According to the method in example 4, 6-(2-Bromo-ethoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole and 2-(methylamino)ethanol were converted to yield 2-[[2-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-ethyl]-methyl-amino]-ethanol, MS: 408 (MH+, 1Br).

Sources & evidence

ORD record
ord-82c74c8209004f0b9112c12360028ac1
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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