Azetidine → 6-(2-Azetidin-1-yl-ethoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole

HRID 270281Notes

Reaction equation

Br[CH2:2][CH2:3][O:4][C:5]1[CH:20]=[CH:19][C:8]2[C:9]([C:12]3[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=3)=[N:10][S:11][C:7]=2[CH:6]=1.[NH:21]1[CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:2][CH2:3][O:4][C:5]2[CH:20]=[CH:19][C:8]3[C:9]([C:12]4[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=4)=[N:10][S:11][C:7]=3[CH:6]=2)[CH2:24][CH2:23][CH2:22]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 22314138HCID 22314138, compound

Product 1

HCID 223141356-(2-Azetidin-1-yl-ethoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole

Procedure

According to the method in example 4, 6-(2-Bromo-ethoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole and azetidine were converted to yield 6-(2-Azetidin-1-yl-ethoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole, MS: 390 (MH+, 1Br).

Sources & evidence

ORD record: ord-c31d2e48905b4f4389703bbbc133a5a5
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07449483B2

Reaction notes

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