3-Butyn-2-amine, 2-methyl- → HCID 22314182, compound

HRID 270298Notes

Reaction equation

HRID 270298 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:22]=[CH:21][C:10]2[C:11]([C:14]3[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][CH:15]=3)=[N:12][S:13][C:9]=2[CH:8]=1.[CH3:23][C:24]([NH2:28])([C:26]#[CH:27])[CH3:25]>>[Br:20][C:17]1[CH:18]=[CH:19][C:14]([C:11]2[C:10]3[CH:21]=[CH:22][C:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:28][C:24]([CH3:25])([CH3:23])[C:26]#[CH:27])=[CH:8][C:9]=3[S:13][N:12]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 763193-Butyn-2-amine, 2-methyl-HCID 22313931HCID 22313931, compound

Product 1

HCID 22314182HCID 22314182, compound

Procedure

According to the method in example 6, 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole and 1,1-dimethylpropargylamine were converted to yield {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-(1,1-dimethyl-prop-2-ynyl)-amine as colorless oil, MS: 443(MH+, 1Br).

Sources & evidence

ORD record
ord-645fb3327869464bb7b31ccae51959ad
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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