Azetidine → HCID 22314081, compound

HRID 270315Notes

Reaction equation

HRID 270315 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH2:19][CH2:20]Br)=[CH:16][C:11]=3[S:10](=[O:23])(=[O:22])[N:9]=2)=[CH:4][CH:3]=1.[NH:24]1[CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:20][CH2:19][CH2:18][O:17][C:15]2[CH:14]=[CH:13][C:12]3[C:8]([C:5]4[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=4)=[N:9][S:10](=[O:23])(=[O:22])[C:11]=3[CH:16]=2)[CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 22314204HCID 22314204, compound

Product 1

HCID 22314081HCID 22314081, compound

Procedure

According to the method in example 9, 3-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[d]isothiazole 1,1-dioxide and azetidine were converted to yield 6-(3-Azetidin-1-yl-propoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole 1,1-dioxide as yellow solid, MS: 435 (MH+, 1Br).

Sources & evidence

ORD record
ord-bf73fe5170704601b85c9d49da3f6931
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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