Azetidine → HCID 22313953, compound

HRID 270316Notes

Reaction equation

HRID 270316 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:24]=[CH:23][C:10]2[C:11]([C:16]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=3)=[N:12][S:13](=[O:15])(=[O:14])[C:9]=2[CH:8]=1.[NH:25]1[CH2:28][CH2:27][CH2:26]1>>[N:25]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:24]=[CH:23][C:10]3[C:11]([C:16]4[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=4)=[N:12][S:13](=[O:14])(=[O:15])[C:9]=3[CH:8]=2)[CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 22313942HCID 22313942, compound

Product 1

HCID 22313953HCID 22313953, compound

Procedure

According to the method in example 9, 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole 1,1-dioxide and azetidine were converted to yield 6-(4-Azetidin-1-yl-butoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole 1,1-dioxide as yellow solid, MS: 449 (MH+, 1Br).

Sources & evidence

ORD record
ord-f7584d870fe1480998c7b10ccf7bc900
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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