Diethanolamine → 2-[{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-(2-hydroxy-ethyl)-amino]-ethanol

Participants

Role	Name	HCID	Charge
Reactant	Diethanolamine	HCID 8113	—
Reactant	Methanesulfonic acid 3-[3-(4-chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl ester	HCID 57428081	—
Product	2-[{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-(2-hydroxy-ethyl)-amino]-ethanol	HCID 22314067	—

Reaction Steps

In analogy to example 16.1, Methanesulfonic acid 3-[3-(4-chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl ester and Diethanolamine (2×2 equivalents) were converted to yield 2-[{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-(2-hydroxy-ethyl)-amino]-ethanol as white solid, MS: 387 (MH+, 1Cl).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07449483B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-44bcf1b0fdf848589b1751b1d1f6d8ee
Source note	uspto-grants-2008_11