Dimethylamine → {3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine

Participants

Role	Name	HCID	Charge
Reactant	Dimethylamine	HCID 674	—
Reactant	Methanesulfonic acid 3-[3-(4-chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl ester	HCID 57428081	—
Solvent	Ethanol	HCID 702	—
Product	{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine	HCID 22313967	—

Reaction Steps

In analogy to example 16.1, Methanesulfonic acid 3-[3-(4-chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl ester and Dimethylamine (10 equivalents of a 5.6 M EtOH solution) were converted to yield {3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine as light brown solid, MS: 327 (MH+, 1Cl).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07449483B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-20dbf85016b04ead8645289ca185539f
Source note	uspto-grants-2008_11