2-(Methylamino)ethanol → HCID 22314070, compound

HRID 270375Notes

Reaction equation

HRID 270375 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13]3[CH:14]=[CH:15][C:16]([CH2:18][CH2:19][CH2:20][CH2:21]OS(C)(=O)=O)=[CH:17][C:12]=3[S:11][N:10]=2)=[CH:5][CH:4]=1.[CH3:29][NH:30][CH2:31][CH2:32][OH:33]>>[CH3:29][N:30]([CH2:21][CH2:20][CH2:19][CH2:18][C:16]1[CH:15]=[CH:14][C:13]2[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:28])([F:1])[F:27])=[CH:4][CH:5]=3)=[N:10][S:11][C:12]=2[CH:17]=1)[CH2:31][CH2:32][OH:33]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 86585424HCID 86585424, compound

Product 1

HCID 22314070HCID 22314070, compound

Procedure

In analogy to example 17.1; Methanesulfonic acid 4-[3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-butyl ester and 2-Methylaminoethanol were converted to yield 2-(Methyl-{4-[3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-butyl}-amino)-ethanol as light yellow oil, MS: 409 (MH+).

Sources & evidence

ORD record
ord-f6765e0d271e49c49c61855b45dd495c
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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