4-Pentyn-1-ol → HCID 22313974, compound

HRID 270466Notes

Reaction equation

HRID 270466 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=[CH:10][C:4]=2[C:3]=1[C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1.[CH2:29]([OH:34])[CH2:30][CH2:31][C:32]#[CH:33]>>[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([C:33]#[C:32][CH2:31][CH2:30][CH2:29][OH:34])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:19]1[CH:20]=[CH:21][C:22]([C:25]([F:26])([F:27])[F:28])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 793464-Pentyn-1-olHCID 86585425HCID 86585425, compound

Product 1

HCID 22313974HCID 22313974, compound

Procedure

In analogy to example 13.1, the Trifluoro-methanesulfonic acid 2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl ester was reacted with 4-pentyn-1-ol to yield the 5-[2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol as brown oil, MS: 374 (M+).

Sources & evidence

ORD record
ord-ac2db2e58cb94251b586d24d722f5824
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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