Methanesulfonyl chloride → HCID 86585428, compound

HRID 270469Notes

Reaction equation

[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][S:27]([CH3:26])(=[O:29])=[O:28])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:23])[F:24])=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22314159HCID 22314159, compound

Product 1

HCID 86585428HCID 86585428, compound

Procedure

In analogy to example 21.1, the 4-[2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-butan-1-ol was treated with methanesulfonic acid chloride to yield the Methanesulfonic acid 4-[2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-butyl ester as yellowish oil, MS: 442 (M+).

Sources & evidence

ORD record: ord-c0ebbd4ffa3840c4bff508dee87c6a7f
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07449483B2

Reaction notes

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