HCID 22314058, compound → HCID 22314001, compound

HRID 270474Notes

Reaction equation

HRID 270474 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20]CO)=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH3:23][O:24][CH2:25][CH2:26][NH:27][CH3:28].[CH2:29](Cl)Cl>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20][CH2:28][N:27]([CH2:26][CH2:25][O:24][CH3:23])[CH3:29])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 22314058HCID 22314058, compoundHCID 131725176HCID 131725176, compound

Product 1

HCID 22314001HCID 22314001, compound

Procedure

In analogy to example 19.1, 5-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol and N-(Methoxyethyl)methylamine CH2Cl2. were converted to yield {5-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-ynyl}-(2-methoxy-ethyl)-methyl-amine as brown oil, MS: 382 (MH+).

Sources & evidence

ORD record
ord-68b31d683f014c8f8ce612d8ef265590
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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