反应详情

温度

55 °C

To a solution of 4-chloro-1-phenylbutan-1-one (26.4 mL, 164 mmol) in DMSO (200 mL) was added sodium azide (12.8 g, 197 mmol). The solution was warmed to 55° C. and stirred for 16 hours. The cooled mixture was then treated with water (600 mL) and extracted with ether (3×200 mL). The combined organics were washed with water (8×100 mL) and brine (100 mL) then dried over MgSO4 and concentrated to provide the product as an orange oil (30.7 g, 99%).

1. extractionextracted with ether (3×200 mL)
2. washThe combined organics were washed with water (8×100 mL) and brine (100 mL)
3. dry with materialthen dried over MgSO4
4. concentrationconcentrated