反应详情

A mixture of 2-chloro-4-(trifluoromethyl)pyridine (2.70 g, 14.9 mmol) and bromotrimethylsilane (3.90 mL, 29.6 mmol) in propanenitrile (15.0 mL) was heated under reflux for 22 h. The product (very volatile) was carefully rotary evaporated to give 4.07 g (propanenitrile contained) of thick light brown suspension w/o further purification. LC-MS calculated for C6H3BrF3N (M+H) 226.9; found 225.9/227.8.

1. temperaturewas heated
2. temperatureunder reflux for 22 h
3. customThe product (very volatile) was carefully rotary evaporated
4. customto give
5. custom4.07 g (propanenitrile contained) of thick light brown suspension w/o further purification