Formaldehyde → 6,7-dihydro-4H-thieno[3,2-c]pyran

Participants

Reaction Steps

20.0 g of 2-thiopheneethanol, 6.1 g of paraformaldehyde, and 1.7 g of indium(III) chloride were added to 1,500 mL of acetonitrile, and the resulting mixture was refluxed for 2 hours. The reaction solution was cooled to room temperature and concentrated by evaporation under reduced pressure. The residue thus obtained was distilled under reduced pressure to obtain 14.4 g (yield of 66%) of the title compound as an oil form.

Provenance & Evidence