HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(Trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1,2-dihydroindazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Dihydro-2-(4-trifluoromethylphenyl)-6-(3-trifluoromethyl-2-pyridinyl)-1-(2-(trimethylsilyl)ethoxymethyl)-3H-indazol-3-one | HCID 86612848 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-(Trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1,2-dihydroindazol-3-one | HCID 11750583 | 45.8% |
Reaction Steps
The product of Step 6 (0.2 g), in a mixture of concentrated HCl (2 mL) and EtOH (3 mL), was heated at reflux for 1 h. The mixture was concentrated and the residue crystallized from EtOH/H2O to give 70 mg of product as a colourless solid. 1H NMR (360 MHz, CDCl3): 7.33 (1H, s), 7.39 (1H, d, J 8.0 Hz), 7.43 (1H, s), 7.5-7.55 (1H, m), 7.73 (2H, d, J 8.0 Hz), 7.99 (1H, d, J 8.0 Hz), 8.09 (2H, d, J 8.0 Hz), 8.14 (1H, d, J 8.0 Hz), 8.9 (1H, d, J 8.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449585B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-a1bbeb0031884ed88efdacba56609217 |
| Source note | uspto-grants-2008_11 |