Sodium Carbonate → 3-chloro-6-(2-methoxyphenyl)-2-(4-trifluoromethylphenyl)-2H-indazole

Participants

Role	Name	HCID	Charge
Reactant	Sodium Carbonate	HCID 10340	—
Reactant	2-Methoxyphenylboronic acid	HCID 2733958	—
Reactant	6-Bromo-3-chloro-2-(4-trifluoromethylphenyl)-2H-indazole	HCID 69201617	—
Catalyst	HCID 178479788	HCID 178479788	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	3-chloro-6-(2-methoxyphenyl)-2-(4-trifluoromethylphenyl)-2H-indazole	HCID 69203383	—

Reaction Conditions

Temperature	160 °C

Reaction Steps

A mixture of the product of Example 1 Step 3 (100 mg, 0.26 mmol), 2-methoxyphenylboronic acid (50 mg, 0.33 mmol), bis(diphenylphosphino)ferrocenyl palladium(II) dichloride 0) (20 mg), saturated Na2CO3 solution (1 mL) and dioxane (2 mL) was heated at 160° C. for 10 min via microwave irradiation. The title product was then purified by preparative thin layer chromatography on silica eluting with EtAc:hexanes 1:5. MS: (ES (M+1)) 403,405.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07449585B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-833e758d4a1b4dc8adbc2c84843ddc42
Source note	uspto-grants-2008_11