Ethyl Acetate → HCID 69292323, compound

Participants

Reaction Steps

2-(2,6-Dichloro-4-nitro-phenyl)-N-(3-formyl-pyridin-4-yl)-acetamide (3.0 g, 8.47 mmol) is dissolved in dry methanol (240 mL). Na2CO3 (1.80 g, 16.94 mmol) is added. The reaction is refluxed for 30 minutes, diluted by ethyl acetate (210 mL) and filtered. The solvents are evaporated to give crude product, which is recrystallized by ethyl acetate/hexanes to give 3-(2,6-dichloro-4-nitro-phenyl)-1H-[1,6]-naphthyridin-2-one as a slightly yellow solid (3.07 g).

Provenance & Evidence