3-(Trifluoromethyl)benzoyl chloride → HCID 59833820, compound

Participants

Reaction Steps

To a solution of 3-(5-amino-2-chloro-phenyl)-1H-[1,6]-naphthyridin-2-one (60 mg, 0.23 mmol) and DIPEA (82 μl, 0.46 mmol) in anhydrous THF (2.5 mL), is added a solution of 3-trifluoromethyl-benzoyl chloride (44 μl). This mixture is stirred for 30 minutes at room temperature, diluted with EtOAc (50 mL), washed with water (10 mL) and brine (10 mL), dried over MgSO4, concentrated and purified by preparative HPLC, to give N-[4-chloro-3-(2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-phenyl]-3-trifluoromethyl-benzamide (18.3 mg).

Provenance & Evidence