反应详情

温度

0 °C

To a solution of 2-chloro-phenyl-acetonitrile (15.0 g, 99.0 mmol) in the dichloromethane (50 mL) and H2SO4 (40 mL) is slowly added a mixture of H2SO4 (14 mL) and HNO3 (5.5 mL) at 0° C. The reaction mixture is stirred at 0° C. for 20 minutes, warmed to room temperature for 30 minutes and then concentrated to remove organic solvent. The solution is poured into a beaker containing ice-water (400 mL) to give a crystalline precipitate, which is collected by vacuum filtration and washed with water to give the title intermediate (13.4 g, 69.0%).

1. temperaturewarmed to room temperature for 30 minutes
2. concentrationconcentrated
3. customto remove organic solvent
4. additionThe solution is poured into a beaker
5. additioncontaining ice-water (400 mL)
6. customto give a crystalline precipitate, which
7. filtrationis collected by vacuum filtration
8. washwashed with water