M-Phenylenediamine → HCID 11433014, compound

Participants

Reaction Conditions

Reaction Steps

3-Aminoaniline (121.1 mg, 1.12 mmonl) is heated to 110° C. When melted, N-[4-chloro-3-(2-methanesulfonyl-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-phenyl]-3-trifluoromethyl-benzamide 34 (15 mg, 0.028 mmol) is added. The reaction is stirred at 110° C. for 25 minutes. The reaction is diluted with MeOH (1 mL) and purified by prep-HPLC to give the final product as a yellow solid: 1H NMR (CDCl3): δ3.64 (s, 3H), 6.66 (d, 1H), 7.17 (t, 1H), 7.28 (d, 1H), 7.42 (m, 2H), 7.48 (t, 1H), 7.50 (dd, 1H), 7.57 (s, 1H), 7.63 (m, 2H), 7.97 (d, 1H), 8.07 (s, 1H), 8.49 (s, 1H); MS m/z 565.0 (M+1).

Provenance & Evidence