Water → 6-(Acetyloxy)-2-naphthalenecarboxylic acid

HRID 270750Notes

Reaction equation

HRID 270750 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=2)[CH:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16].O>C(O)(=O)C>[C:15]([O:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=2)[CH:3]=1)(=[O:17])[CH3:16]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 855576-Hydroxy-2-naphthoic acid

Product 1

HCID 870386-(Acetyloxy)-2-naphthalenecarboxylic acidYield 97%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

18.8 g of 2-hydroxynaphthalene-6-carboxylic acid was reacted with 94 g of acetic anhydride in 94 g of acetic acid at 80° C. for 4 hours. The reaction liquid was poured to 500 g of water and the precipitate was filtrated and washed thoroughly with methanol and water and then dried to give 22.3 g of 2-acetoxynaphthalene-6-carboxylic acid.

Workup

  1. customThe reaction liquid
  2. filtrationthe precipitate was filtrated
  3. washwashed thoroughly with methanol and water
  4. customdried

Sources & evidence

ORD record
ord-2937fe26629c44aa804d0542f8438e12
Source dataset
uspto-grants-2008_11
Patent number
US07449608B2

Reaction notes

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