反应详情

温度

-35 °C

Dissolve methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester (8.8 g, 35.4 mmol) in ether (80 mL) and cool to -35° C. Add potassium t-butoxide (10 g, 89 mmol) and stir for 30 minutes. Add water (50 mL) and ether (150 mL), extract, dry (Na2SO4) and purify by silica gel chromatography (2:3 methylene chloride/pentane) to give 1-chloromethyl-2-vinyl-benzene as a colorless oil (4.43 g, 82%).

1. extractionAdd water (50 mL) and ether (150 mL), extract
2. dry with materialdry (Na2SO4)
3. custompurify by silica gel chromatography (2:3 methylene chloride/pentane)