HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid → 4-{4-[2-(4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid | HCID 1876853 | — |
| Reactant | 4-(Piperazin-1-yl)benzonitrile | HCID 2733995 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Product | 4-{4-[2-(4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-benzonitrile | HCID 21071138 | — |
Reaction Steps
Title compound was prepared following the HATU mediated coupling protocol P, wherein 1-(4-Cyanophenyl)-piperazine and (4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid were used as the coupling components, to give the product as a solid: 1H NMR (CDCl3, 400 MHz) 7.44 (d, 2H), 6.77 (d, 2H), 4.90 (s, 2H), 3.67 (m, 4H), 3.29 (m, 4H), 2.22 (s, 3H) ppm; MS (ES) M+Na expected=434.0, found 434.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449576B1 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-37fad470d94f446dba3a1f8f9a9e84ae |
| Source note | uspto-grants-2008_11 |