HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-Chloro-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Chloro-3-methoxyphenyl)piperazine | HCID 21071024 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 2-Chloro-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethanone | HCID 21071126 | — |
Reaction Steps
Protocol S was followed using 1-(4-chloro-3-methoxyphenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compounds as a white solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449576B1 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5c244e2cb0bf40d7992f3c34107868a9 |
| Source note | uspto-grants-2008_11 |