7-Cyclohexyl-6-[4-(2,4-dimethyl-thiazol-5-ylmethoxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrile → HCID 178432759, compound

HRID 270944Notes

Reaction equation

HRID 270944 reaction equation
C1(C2N3N=CC(C#N)=C3N=CC=2C2C=CC(OCC3SC(C)=NC=3C)=CC=2)CCCCC1.[CH:33]1([C:39]2[N:44]3[N:45]=[CH:46][C:47]([C:48]4[NH:52][N:51]=[N:50][N:49]=4)=[C:43]3[N:42]=[CH:41][C:40]=2[C:53]2[CH:58]=[CH:57][C:56]([O:59][CH2:60][C:61]3[S:65][C:64]([CH3:66])=[N:63][C:62]=3[CH3:67])=[CH:55][CH:54]=2)[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1.N1C=NN=N1>>[CH:33]1([C:39]2[N:44]3[N:45]=[CH:46][C:47]([C:48]4[NH:49][N:50]=[N:51][N:52]=4)=[C:43]3[N:42]=[CH:41][C:40]=2[C:53]2[CH:58]=[CH:57][C:56]([O:59][CH2:60][C:61]3[S:65][C:64]([CH3:66])=[N:63][C:62]=3[CH3:67])=[CH:55][CH:54]=2)[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1

Participants

3

Reactant 2

HCID 184458817-Cyclohexyl-6-[4-(2,4-dimethyl-thiazol-5-ylmethoxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrileHCID 178432760HCID 178432760, compound

Product 1

HCID 178432759HCID 178432759, compound

Procedure

Conversion of 7-cyclohexyl-6-[4-(2,4-dimethyl-thiazol-5-ylmethoxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrile to the corresponding tetrazole 7-cyclohexyl-6-[4-(2,4-dimethyl-thiazol-5-ylmethoxy)-phenyl]-3-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidine (358) was accomplished via a procedure described elsewhere.

Sources & evidence

ORD record
ord-6320893899b14e3fb4eb3b51ebfe3816
Source dataset
uspto-grants-2008_11
Patent number
US07449488B2

Reaction notes

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