反应详情

温度

0 °C

To an ice cold suspension of 0.92 g (23 mmol) of sodium hydride (NaH 60% dispersion in mineral oil) (previously washed with hexane and dried under vacuum) in 25 mL of 1,2-dimethoxyethane (DME) was added 0.9 g (5.76 mmol) of methyl cyclohexylacetate, and the resulting mixture was stirred at 0° C. for 20 min. Then 1.2 g (8.56 mmol) of ethyl 2-furoate was added, and the reaction mixture was heated at reflux overnight. The mixture was then cooled to 0° C., quenched by the addition of 1 M HCl solution to pH=3, and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sulfate and concentrated to give a brown oil which was chromatographed on silica gel (Biotage; 10% hexane in dichloromethane) to afford 1.1 g (76% yield) of desired 2-cyclohexyl-3-furan-2-yl-3-oxo-propionic acid methyl ester as indicated by 1H NMR.

1. washpreviously washed with hexane
2. dry with materialdried under vacuum) in 25 mL of 1,2-dimethoxyethane (DME)
3. temperaturethe reaction mixture was heated
4. temperatureat reflux overnight
5. temperatureThe mixture was then cooled to 0° C.
6. customquenched by the addition of 1 M HCl solution to pH=3
7. extractionextracted with ethyl acetate
8. washThe combined organic extracts were washed with brine
9. dry with materialdried over sodium sulfate
10. concentrationconcentrated
11. customto give a brown oil which
12. customwas chromatographed on silica gel (Biotage; 10% hexane in dichloromethane)