Acetic Anhydride → HCID 85437380, compound

HRID 271058Notes

Reaction equation

HRID 271058 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:14])[CH2:9][C:10]([O:12][CH3:13])=[O:11].[CH2:15]([O:17][CH:18](OCC)OCC)[CH3:16].[C:25](OC(=O)C)(=O)C>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:9](=[CH:18][O:17][CH2:15][CH3:16])[C:10]([O:12][CH2:13][CH3:25])=[O:11])=[O:14]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 735887methyl 3-(2-chlorophenyl)-3-oxopropanoate

Product 1

HCID 85437380HCID 85437380, compound

Conditions

Temperature
130 °C

Procedure

To a flask containing 3-(2-chlorophenyl)-3-oxo-propionic acid, methyl ester (20 g, 94 mmol) was added triethylorthoformate (37.5 mL, 225.6 mmol) and acetic anhydride (63 mL, 667 mmol). The resulting mixture was heated to 130° C. with stirring for a total of 2 hours, then stirred over night at room temperature. The reaction mixture was concentrated under reduced pressure to provide a crude oil, which was used directly in the next step.

Workup

  1. stirringstirred over night at room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto provide a crude oil, which

Sources & evidence

ORD record
ord-e5bd7a91dc5b4c91be5a334bdbf82cd0
Source dataset
uspto-grants-2008_11
Patent number
US07452880B2

Reaction notes

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