Water → HCID 53415539, compound

Participants

Reaction Steps

To a solution of 4-[(3-bromophenyl)ethynyl]pyridine (1.81 g, 7.0 mmol) in acetone (63 mL) is added a warm (˜40° C.) solution of NaHCO3 (0.35 g, 4.20 mmol) and MgSO4 (1.26 g, 10.50 mmol) in H2O (63 mL) followed by the addition of solid potassium permanganate (2.43 g, 15.40 mmol) in one portion. After stirring at room temperature for 4 minutes, the reaction mixture is extracted with 1/1 Et2O/hexane. The extracts are combined, dried over MgSO4 and concentrated to dryness to afford the title compound (1.52 g, 75%) as a solid. Mp: 88-90° C. MS (+) ES: 289 (M+H)+.

Provenance & Evidence