Water → 3-Chloro-1-phenylpyrrolidin-2-one

HRID 271232Notes

Reaction equation

HRID 271232 reaction equation
[C:1]1([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C.S([Cl:33])(C1C=CC(C)=CC=1)(=O)=O.O>C1COCC1.CCOC(C)=O>[Cl:33][CH:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]1=[O:12]

Participants

7

Reactant 4

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 783751-Phenylpyrrolidin-2-oneHCID 2733832Lithium Hexamethyldisilazide

Product 1

HCID 219355593-Chloro-1-phenylpyrrolidin-2-one

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

1-Phenyl-2-pyrrolidinone (1 g, 6.2 mmol) in THF (60 mL, anhydrous) was cooled to −40° C. and LiHMDS (8 mL, 8 mmol, 1 M soln. in THF) was added. The resulting solution was stirred for 40 min. and tosyl chloride (1.78 g, 9.33 mmol) was then added. After warming the solution to RT over a 14 hour period, H2O added to quench reaction. The solution was then concentrated to provide an oil. Next, the oil was redissovled in EtOAc and washed with H2O and brine. The organic layer was dried over Na2SO4, filtered, and concentrated to an oil once again. Purified via flash column chromatography (4:1 hexane/EtOAc) provided 3-chloro-1-phenylpyrrolidin-2-one.

Workup

  1. additionadded
  2. customto quench
  3. customreaction
  4. concentrationThe solution was then concentrated
  5. customto provide an oil
  6. washwashed with H2O and brine
  7. dry with materialThe organic layer was dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated to an oil once again
  10. customPurified via flash column chromatography (4:1 hexane/EtOAc)

Sources & evidence

ORD record
ord-1690da9ee9d04d15a9e902f5e916c3ee
Source dataset
uspto-grants-2008_11
Patent number
US07452889B2

Reaction notes

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