Ethanol → Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 271235Notes

Reaction equation

HRID 271235 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

Product 1

HCID 21935588Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

Conditions

Temperature
0 °C

Procedure

1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (unknown amount) was dissolved in 20 ml ethanol and cooled to 0° C. HCl gas was bubbled into the solution until the solution became red in color. The reaction was allowed to warm to room temperature and stir ovenight. The solvent was removed to yield ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (M+1=251.93).

Workup

  1. customHCl gas was bubbled into the solution until the solution
  2. temperatureto warm to room temperature
  3. customThe solvent was removed

Sources & evidence

ORD record
ord-3c074810df3c4d3c99c269f3996b7ca9
Source dataset
uspto-grants-2008_11
Patent number
US07452889B2

Reaction notes

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