HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-[(3r)-1-(4-Chlorophenyl)-2-oxopyrrolidin-3-yl](phenylmethoxy)carboxamide → (3R)-3-amino-1-(4-chlorophenyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-[(3r)-1-(4-Chlorophenyl)-2-oxopyrrolidin-3-yl](phenylmethoxy)carboxamide | HCID 21060625 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Cyclohexene | HCID 8079 | — |
| Product | (3R)-3-amino-1-(4-chlorophenyl)pyrrolidin-2-one | HCID 58714338 | — |
Reaction Steps
To a solution of N-[(3R)-1-(4-chlorophenyl)-2-oxopyrrolidin-3-yl](phenylmethoxy)carboxamide (0.2 g, 0.58 mmol) in ethanol (10 ml) and cyclohexene (4 ml) was added palladium hydroxide (40 mg). The reaction was refluxed vigorously overnight. Palladium was removed by filtration and the filtrate was concentrated to yield (3R)-3-amino-1-(4-chlorophenyl)pyrrolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452889B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-9704df48e6c64055b65f54956a2424ab |
| Source note | uspto-grants-2008_11 |