HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 271258Generated: October 26, 2026
Triethylamine → 9-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine
https://huagongshe.com/reaction/271258
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-t-Butylbenzenesulfonyl chloride | HCID 139882 | — |
| Reactant | 6-(furan-2-yl)-9H-purin-2-amine | HCID 178508247 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine | HCID 59835041 | 53.3% |
Reaction Steps
A solution of 6-(2-furyl)-1H-purine-2-amine (100 mg, 0.5 mmol) in THF (2 mL) and DMF (0.5 mL) was treated with 4-tert-butylbenzenesulphonyl chloride (116 mg, 0.5 mmol) and Et3N (69 μL, 0.6 mmol), heated at 60° C. for 2 h, cooled, diluted with water and the resulting solid filtered and washed with EtOAc to give the title compound (106 mg, 53%) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07452894B2 |
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| Source dataset | uspto-grants-2008_11 |
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| ORD ID | ord-9f7350dd144c4e8ab165d5d6335c9ddb |
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| Source note | uspto-grants-2008_11 |
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